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Subject: New article submission by bilal Ahmad for Sandarbh!
Date: Sun, 2 Feb 2020 11:49:08 +0530
From: Eklavya Team <[email protected]>
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=0ADear Sandarbh Team,
=0AYou have a new article submission on Eklavya's website.
=0ASubmission details are.......
=0AName: bilal Ahmad
=0AEmail: [email protected]
=0ASubject: CORONAVIRUSES(CoVs)- A GLOBAL EMERGENCY
=0AContent/Article:
=0ACoronaviruses (CoVs) were identified in 1965 to infect birds and mammals=
. They were so named because of the spike proteins emanated from these viru=
ses which gave them a crownlike appearence. Coronaviruses are known to be 2=
0 nm long and are recognised by club shaped surface projections and resembl=
e like solar coronas. These viruses are characterized by their ability to C=
ause the common cold especially in older childrens and adults. They represe=
nt order Nidovirals, faimly Coronaviridae, subfaimly  Coronavirinae. they a=
re relatively large (120-150 nm), composed of +ive strand  RNA varying in l=
ength from 26 to 32 kilobases (kb) (largest genome for RNA viuses) within t=
he helical nucleocapside,  surrounded by the envelope. The envelope protein=
s are coded by The CoV E protein that has recently been found to contain a =
binding motif known as the postsynaptic density protein 95 (PSD95). This do=
main is a protein-protein interaction module that can bind to the target pr=
oteins such as the cellular adapter proteins involved in host-cell processe=
s important for viral infection. Corona viruses have been classified into t=
hree main categories based on the antigenic criteria; =CE=B1-CoVs, =CE=
=B2-CoVs, and =CE=BCCoVs. Large peplomers (spikes) come out of the envelope=
 in order to help bind and enter the virus in the host cell. The protruding=
 peplomers extend from the oval to spherical virion to give the illusion of=
 a halo, or corona, around the virus. The peplomer protein mediates viral a=
ttachment and fusion to the host cell membrane.=0A
=0A
A new type of corona virus has emerged from the city of Wuhan in china name=
d as 2019 Novel Coronavirus (2019-nCoV). Within weeks, it has spread to the=
 several countries and has killed many people. Infection of this novel coro=
navirus causes respiratory illness among humans. Patients with 2019-nCoV ha=
ve reportedly had shortness of breath, fever, cough and severe complication=
s include pneumonia in both lungs. Coronaviruses are a large group among bi=
rd and mammals but in rare cases like this one, they are transmitted betwee=
n humans- a process known as zoonosis but it is still unclear whether this =
happens routinely. This new virus is the seventh known corona virus but is =
considered not as deadly as SARS that killed 11%of people it infected.=0A
Though there are several human CoV responsible for a mild respiratory disea=
se, most notable are the highly pathogenic human CoVs: SARS-CoV and MERS-Co=
V capable of causing a severe respiratory disease=0A
The initial outbreak of SARS originated in chaina in late 2002, and it spre=
ad rapidly to atleast 29 other countries by summer 2003. The outbreak resul=
ted in 8098 persons with possible SARS, including 744 deaths being reported=
 by WHO. There were 373 possible SARS cases in the united states; however, =
SARS-CoV identification has been confirmed only in 8 of them.  seven of the=
 eight cases were likely due exposure to one of the other seven. The 2003 S=
ARS epidemic demonstrated to the world the ease with which a virus can spre=
ad. SARS-CoV virions use the angiotensin-converting enzyme 2 (ACE2) on the =
host cells as the virus receptor. A receptor-binding domain of the peplomer=
 is complementary to the ACE2 receptor creating a binding interface.=0A
 =0A
The coronavirus that caused the outbreakof severe acute respiratory syndrom=
e, or SARS. =0A
(a) The virus is studded with spikes that in cross-section give it the appe=
arance of acrown, hence the name coronavirus.=0A
 (b) The human receptor for the SARS virus is angiotensin-converting enzyme=
 2 (ACE2). =0A
  The virus causes a lower respiratory tract disease which is febrile (100.=
4, 38oc). Sudden, fatal illness is a characteristic of the disease in peopl=
e who are otherwise healthy. Other signs may include headache, pain with th=
e flulike discomfort; and body aches. After a couple of days, patients may =
develop a dry cough, and most will develop pneumonia. Approximately 10-20 p=
er cent has diarrhoea. If not detected early, even with supportive care, th=
is illness can be fatal. Rapid detection and prevention measures were pursu=
ed during and after the outbreak. Diligent screening for signs of fever or =
respiratory disease at airports and the initiation of SARS-CoV vaccine trai=
ls are two examples of protective measures. =0A
=0A
The researchers believe that the novel coronavirus (2019-nCoV) was orginate=
d in the Wuhan market by an unknown species. Identifying that animal could =
help control the current outbreak. No known medicines are currently approve=
d which can effectively treat infections of Coronavirus in humans and no va=
ccines are currently licensed. It could be helpful to prevent infection by =
blocking the receptor used by the virus to infect the cell. The high mortal=
ity rates of novel coronavirus (2019-nCoV) and their effective transmission=
 underline the need for further research to highlight the specific structur=
al requirements for its function in the life cycle  and mechanisms behind t=
heir pathogensis. This will help in the production effective anticoronavira=
l agents.=0A

=0A------------ end of content/article ----------
=0AWeb Admin=0AEklavya, Bhopal

--b1_a7ee89f0a545230593500da17147d13d
Content-Type: text/html; charset=utf-8
Content-Transfer-Encoding: quoted-printable

<p>Dear Sandarbh Team,</p>
<p>You have a new article submission on Eklavya's website.</p>
<p>Submission details are.......</p>
<p>Name: <strong>bilal Ahmad</strong></p>
<p>Email: <strong>[email protected]</strong></p>
<p>Subject: <strong>CORONAVIRUSES(CoVs)- A GLOBAL EMERGENCY</strong></p>
<p><strong><span style=3D"text-decoration: underline;">Content/Article:</sp=
an></strong></p>
<p>Coronaviruses (CoVs) were identified in 1965 to infect birds and mammals=
. They were so named because of the spike proteins emanated from these viru=
ses which gave them a crownlike appearence. Coronaviruses are known to be 2=
0 nm long and are recognised by club shaped surface projections and resembl=
e like solar coronas. These viruses are characterized by their ability to C=
ause the common cold especially in older childrens and adults. They represe=
nt order Nidovirals, faimly Coronaviridae, subfaimly  Coronavirinae. they a=
re relatively large (120-150 nm), composed of +ive strand  RNA varying in l=
ength from 26 to 32 kilobases (kb) (largest genome for RNA viuses) within t=
he helical nucleocapside,  surrounded by the envelope. The envelope protein=
s are coded by The CoV E protein that has recently been found to contain a =
binding motif known as the postsynaptic density protein 95 (PSD95). This do=
main is a protein-protein interaction module that can bind to the target pr=
oteins such as the cellular adapter proteins involved in host-cell processe=
s important for viral infection. Corona viruses have been classified into t=
hree main categories based on the antigenic criteria; =CE=B1-CoVs, =CE=
=B2-CoVs, and =CE=BCCoVs. Large peplomers (spikes) come out of the envelope=
 in order to help bind and enter the virus in the host cell. The protruding=
 peplomers extend from the oval to spherical virion to give the illusion of=
 a halo, or corona, around the virus. The peplomer protein mediates viral a=
ttachment and fusion to the host cell membrane.<br />
<br />
A new type of corona virus has emerged from the city of Wuhan in china name=
d as 2019 Novel Coronavirus (2019-nCoV). Within weeks, it has spread to the=
 several countries and has killed many people. Infection of this novel coro=
navirus causes respiratory illness among humans. Patients with 2019-nCoV ha=
ve reportedly had shortness of breath, fever, cough and severe complication=
s include pneumonia in both lungs. Coronaviruses are a large group among bi=
rd and mammals but in rare cases like this one, they are transmitted betwee=
n humans- a process known as zoonosis but it is still unclear whether this =
happens routinely. This new virus is the seventh known corona virus but is =
considered not as deadly as SARS that killed 11%of people it infected.<br /=
>
Though there are several human CoV responsible for a mild respiratory disea=
se, most notable are the highly pathogenic human CoVs: SARS-CoV and MERS-Co=
V capable of causing a severe respiratory disease<br />
The initial outbreak of SARS originated in chaina in late 2002, and it spre=
ad rapidly to atleast 29 other countries by summer 2003. The outbreak resul=
ted in 8098 persons with possible SARS, including 744 deaths being reported=
 by WHO. There were 373 possible SARS cases in the united states; however, =
SARS-CoV identification has been confirmed only in 8 of them.  seven of the=
 eight cases were likely due exposure to one of the other seven. The 2003 S=
ARS epidemic demonstrated to the world the ease with which a virus can spre=
ad. SARS-CoV virions use the angiotensin-converting enzyme 2 (ACE2) on the =
host cells as the virus receptor. A receptor-binding domain of the peplomer=
 is complementary to the ACE2 receptor creating a binding interface.<br />
 <br />
The coronavirus that caused the outbreakof severe acute respiratory syndrom=
e, or SARS. <br />
(a) The virus is studded with spikes that in cross-section give it the appe=
arance of acrown, hence the name coronavirus.<br />
 (b) The human receptor for the SARS virus is angiotensin-converting enzyme=
 2 (ACE2). <br />
  The virus causes a lower respiratory tract disease which is febrile (100.=
4, 38oc). Sudden, fatal illness is a characteristic of the disease in peopl=
e who are otherwise healthy. Other signs may include headache, pain with th=
e flulike discomfort; and body aches. After a couple of days, patients may =
develop a dry cough, and most will develop pneumonia. Approximately 10-20 p=
er cent has diarrhoea. If not detected early, even with supportive care, th=
is illness can be fatal. Rapid detection and prevention measures were pursu=
ed during and after the outbreak. Diligent screening for signs of fever or =
respiratory disease at airports and the initiation of SARS-CoV vaccine trai=
ls are two examples of protective measures. <br />
<br />
The researchers believe that the novel coronavirus (2019-nCoV) was orginate=
d in the Wuhan market by an unknown species. Identifying that animal could =
help control the current outbreak. No known medicines are currently approve=
d which can effectively treat infections of Coronavirus in humans and no va=
ccines are currently licensed. It could be helpful to prevent infection by =
blocking the receptor used by the virus to infect the cell. The high mortal=
ity rates of novel coronavirus (2019-nCoV) and their effective transmission=
 underline the need for further research to highlight the specific structur=
al requirements for its function in the life cycle  and mechanisms behind t=
heir pathogensis. This will help in the production effective anticoronavira=
l agents.<br />
</p>
<p>------------ end of content/article ----------</p>
<p><strong>Web Admin</strong><br />Eklavya, Bhopal</p>


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